Treatment of Critical Illness Polyneuromyopathy

Completed · Not applicable

Conditions studied: Acute Respiratory Failure

In brief

Acute respiratory failure is a heterogeneous disorder that results in more than 300,000 Americans requiring admission to an intensive care unit for invasive mechanical ventilatory support each year. Though acute respiratory failure is a pulmonary disorder, patients who survive their hospitalization are not limited by respiratory symptoms after discharge. Rather persistent neuromuscular weakness is the primary disorder that adversely alters their quality of life and ability to function on a daily basis. In this application the investigators plan to conduct a randomized clinical trial called the Do It Now study (Diagnosis and Treatment of Neuromuscular Weakness) to determine the effectiveness of an intensive physical therapy program for patients recovering from acute respiratory failure. This trial will establish the efficacy of the physical therapy programs that is currently performed for patients with acute respiratory failure in a non-evidence based manner across the United States.

Key facts

Study ID

NCT01058421

Run by

University of Colorado, Denver

People needed

120

Starts

2009-09-01

Expected to finish

2015-10-01

Last updated by the study team

2017-04-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Acute respiratory failure requiring mechanical ventilation for at least four days.

You may not qualify if…

• Recent myocardial infarction within the last 3 weeks, presence of signs or symptoms of unstable angina or history of unstable arrhythmias including ventricular tachycardia and atrial fibrillation (HR > 100 bpm).
• Recent history of pulmonary embolism within the last six weeks.
• History of severe aortic stenosis.
• Presence of a dissecting aortic aneurysm.
• Significant language barrier that would limit the ability to participate in the physical therapy program.
• Patients who live greater than 45 miles from the University of Colorado Hospital.
• Underlying disorder that makes it unlikely that the patient will survive 6 months.
• Severe physical or cognitive impairment that would impair their ability to exercise.

Where it is running

• Medical Center of Aurora — Aurora, Colorado, United States
• University of Colorado Denver — Aurora, Colorado, United States
• Rose Medical Center — Denver, Colorado, United States
• Swedish Medical Center — Englewood, Colorado, United States
• St. Anthony Hospital — Lakewood, Colorado, United States

Full record on ClinicalTrials.gov

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