Effects of Botulinum Toxin in Cervical Dystonia

Completed

Conditions studied: Torticollis, Cervical Dystonia

In brief

Botulinum toxin injection in the contracting muscles has proven to be a safe and effective method of relieving pain and lessening dystonic posturing. The current hypothesis is that botulinum toxin works on altering sensory input in the central nervous system in addition to its effects on the neuromuscular junction. Magnetoencephalography (MEG)of brain has been used in dystonia such as writer's cramp and musician's hand dystonia. However, no study has investigated the correlation of central signal changes via magnetoencephalography before and after treatment with botulinum in torticollis patients. Prior studies using somatosensory potentials indicated the possibility of differential activation of precentral cortex in patients with cervical dystonia. Cervical dystonia may result from a disorder of both cortical excitability and intracortical inhibition. The investigators hypothesis is that botulinum injection modulates central inhibition which improves clinical outcome for torticollis.

Key facts

Study ID

NCT01056861

Run by

Henry Ford Health System

People needed

7

Starts

2010-01-01

Expected to finish

2014-07-01

Last updated by the study team

2015-04-17

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• male or female subjects 18 years to 90 years
• females who are child bearing potential, with negative pregnancy testing, who are willing to use reliable form of contraception during the study
• subjects meeting the criteria for torticollis

You may not qualify if…

• intracranial metal objects generating significant magnetic artifact
• females who are pregnant, planning pregnancy, unable to use contraception
• mental instability
• any medical condition that may put the subject at increased risk with exposure to botulinum toxin, allergy or sensitivity
• significant head tremor

Where it is running

• Henry Ford Hospital — Detroit, Michigan, United States

Full record on ClinicalTrials.gov

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