Effects of Nebivolol on Exercise Tolerance and Left Ventricular Systolic and Diastolic Function
Completed · Not applicable
Conditions studied: Hypertension
In brief
The goal of this pilot study is to effectively treat hypertension in subjects with either known or newly diagnosed hypertension and concurrent evidence of diastolic dysfunction. Due to the unique properties of nebivolol, it is hypothesized that there will be improvements in left ventricular (LV) systolic and diastolic function manifesting as increase exercise capacity in this patient population with primarily LV diastolic dysfunction. The present study was performed to determine the effects of nebivolol on blood pressure, exercise tolerance and parameters of left ventricular systolic and diastolic function in a group of hypertensive patients with echocardiographic evidence diastolic dysfunction.
Key facts
- Study ID
- NCT01056718
- Run by
- Mercy Research
- People needed
- 53
- Starts
- 2009-11-01
- Expected to finish
- 2014-05-01
- Last updated by the study team
- 2017-04-18
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis (new or established) hypertension, defined by serial measurements >/= 140/90
- Evidence of diastolic dysfunction on echocardiography measured by tissue Doppler
You may not qualify if…
- Severe bronchospastic disease/ reactive airway disease
- Inability to tolerate beta blocker therapy including: >1st degree atrioventricular (AV) block, symptomatic hypotension, symptomatic bradycardia,
- Subjects with physical limitations that would prevent them from participating in an exercise treadmill test
- Age <18 or >90 years
- Those with life expectancy <1 year
- Subjects with class III/IV New York Heart Association (NYHA) heart failure symptoms
- Chronic Kidney Disease 3 or greater (CrCl <30 cc/min)
- Subjects with active ischemia or evidence of ischemia on initial stress echocardiography
Where it is running
- St. John's Mercy Cardiovascular Research — St Louis, Missouri, United States
Full record on ClinicalTrials.gov
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