Neuromodulation of Trauma Memories in PTSD & Alcohol Dependence

Completed · Phase 2 · Has a placebo group

Conditions studied: Alcohol Dependence, PTSD

In brief

The purpose of this study is to examine the effect of propranolol versus placebo on craving, distress and cue reactivity to trauma and alcohol cues.

Key facts

Study ID

NCT01055171

Run by

Medical University of South Carolina

People needed

44

Starts

2010-01-01

Expected to finish

2012-08-01

Last updated by the study team

2016-03-08

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participants must meet DSM-IV criteria for current alcohol dependence
• Participants must have experienced criminal victimization
• Use of birth control by female participants
• Live within a 50-mile radius of research site
• Consent to remain abstinent of all drugs and alcohol for 24 hours prior to patient admission and follow-up
• Consent to random assignment to propanol or placebo
• Individuals must be able to provide informed consent and function at an intellectual level sufficient to allow accurate completion of all assessment instruments.

You may not qualify if…

• Women who are pregnant, nursing or are of childbearing potential and not using birth control.
• Evidence or history of significant hematological, endocrine, cardiovascular, pulmonary, renal, gastrointestinal or neurological disease
• Significant liver impairment
• Currently taking anti-arrhythmic agents, psychostimulants or other agents known to interfere with heart rate and skin conductance monitoring.
• Known or suspected hypersensitivity to propanol
• Individuals taking medication that could adversely interact with the study medication, including the following: albuterol, insulin or significant inhibitors of CYP2D6
• Individuals with bronchial asthma or chronic obstructive pulmonary disease
• Prospective participants will be excluded if they are currently receiving exposure-based therapy for PTSD.
• Individuals with a history of or current psychotic disorder.
• Individuals with Addison's disease, Cushing's disease or other diseases of the adrenal cortex likely to affect cortisol levels.
• Individuals receiving synthetic glucocorticoid therapy, any exogenous therapy, or treatment with other agents that interfere with HPA axis function within one month of the time of testing.
• Individuals with resting heart rates less than 55 bpm.

Where it is running

• MUSC — Charleston, South Carolina, United States

Full record on ClinicalTrials.gov

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