Molecular Mechanisms of Mitral Regurgitation-Aim 2
Completed
Conditions studied: Mitral Regurgitation
In brief
The investigators hypothesize that MR in humans is characterized by adrenergic overdrive, reactive nitrogen species, and an antifibrotic phenotype that relate to the severity of adverse LV remodeling prior to surgery and outcome after valve repair.
Key facts
- Study ID
- NCT01052532
- Run by
- University of Alabama at Birmingham
- People needed
- 65
- Starts
- 2005-06-01
- Expected to finish
- 2010-11-01
- Last updated by the study team
- 2010-12-02
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 21 years old or older.
- Severe MR by echo or catheterization without evidence of ischemia requiring surgery documented by cardiac catheterization and/or maximal stress test with myocardial perfusion imaging.
You may not qualify if…
- Significant obstructive coronary artery disease and/or myocardial ischemia on graded exercise test with myocardial perfusion.
- Previous myocardial infarction.
- Hypertrophic cardiomyopathy, congenital or pericardial disease.
- Aortic valve disease (> trace aortic regurgitation or mean gradient > 10 mmHg)
- Mitral stenosis (mean gradient > 5 mmHg, valve area < 1.5 cm2).
- Renal failure with creatinine > 2.5 mg/dl.
- Renal artery stenosis.
- Severe comorbidity such as liver disease, malignancy, collagen vascular disease, or chronic steroid requirement.
- Pregnancy (negative pregnancy test and effective contraceptive methods are required prior to enrollment of females of childbearing potential (not post-menopausal or surgically sterilized).
- Exclusion Criteria Related to MRI
- Severe claustrophobia.
- Presence of a pacemaker or non-removable hearing aid.
- Presence of metal clips in the body.
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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