Improving Muscle for Functional Independence Trial

Completed · Not applicable

Conditions studied: Obesity

In brief

Aging is associated with declines in muscle strength, power, and overall functional ability that lead to disability and loss of independence. Furthermore, the existing high prevalence of obesity in the elderly is greatly exacerbating these aging-related declines in function. To date, regular exercise, especially resistance exercise, is the only known treatment to consistently improve muscle function and perhaps delay the onset of disability. However, not all individuals experience the same magnitude of benefit from a given exercise stimulus, and accumulating data show that obesity limits muscle adaptations to chronic exercise.Therefore, the proposed study is designed to determine the effects of caloric restriction on improvements in skeletal muscle function in response to RT.

Key facts

Study ID

NCT01049698

Run by

Wake Forest University

People needed

126

Starts

2010-02-01

Expected to finish

2014-05-01

Last updated by the study team

2018-08-01

Who can join

Age: 65 and older, up to 79. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• BMI=27-34.9 kg/m2
• No resistance training for past 6 mos
• Normal cognitive function (MMSE >24)
• No contraindications for participation in weight loss or resistance exercise including severe arthritis or musculoskeletal disorders, knee or hip replacement or spinal surgery in past year
• No broken bones in the past 6 months
• Able to provide own transportation to study visits and intervention
• Not involved in any other research study and not undergoing physical therapy
• Not dependent on a cane or walker

You may not qualify if…

• Weight loss or gain (±5%) in past 6 months
• Body mass >136 kg (DXA limit)
• Current smoker (No nicotine within past year) or evidence of alcohol or drug abuse
• Insulin dependent or uncontrolled diabetes (FBG >140 mg/dL)
• Uncontrolled hypertension (BP>180/100 mmHg)
• Abnormal kidney function or liver blood tests
• Past or current cardiovascular disease, including uncontrolled angina or dysrhythmia, hypertrophic cardiomyopathy, congestive heart failure, PAD, stroke, history of myocardial infarction, use of defibrillator or major heart surgery, or deep vein thrombosis or pulmonary embolus
• Past or current respiratory disease (requiring steroid treatment or supplemental oxygen)
• Past or current clinical diagnoses of neurological or hematological disease
• Use of any medications that could influence study variables (growth/steroid hormones, prescription anti-inflammatory medications, or beta blockers, Coumadin or any other blood thinner, including Plavix, Ticid, and Aggrenox)
• Cancer requiring treatment in past 2 years, except non-melanoma skin cancers
• Clinically evident edema or anemia

Where it is running

• Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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