Randomized Controlled Trial of Silymarin in Asthma
Withdrawn before enrolling · Phase 2/Phase 3 · Has a placebo group
Conditions studied: Atopic Asthma
In brief
The purpose of this study is to determine if intake of the antioxidant enzyme inducer, silymarin, will improve lung function and symptom scores in participants with asthma.
Key facts
- Study ID
- NCT01049178
- Run by
- Vanderbilt University
- People needed
- 0
- Starts
- 2010-09-01
- Expected to finish
- 2010-09-01
- Last updated by the study team
- 2014-02-24
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Inclusion Criteria Male or female subject with confirmed asthma, AND
- Age ≥ 18 years
- Asthma Control Test (ACT) Score of 15-20, AND
- Documented atopy by prick skin testing (most study participants will likely have participated in one of the investigators prior observational studies and will have had skin testing, if not, this will be performed at an in-person screening visit), AND
- For women: Not pregnant, as determined by a negative urinary pregnancy test at the initial visit(visit 1), AND at the start of the cross-over period (visit 4), AND using birth control
You may not qualify if…
- Known allergies to plants in the Asteraceae family (thistles, daisies, artichokes, kiwi)
- Non-asthmatic, or inadequate documentation which includes lack of signs and symptoms of asthma, or lack of prior confirmatory testing
- Pregnant
- Age < 18 years
- Non-English speaking
- Current smoker (current, or within last year)
- Chronic Obstructive Pulmonary Disease(COPD)
- Unable to swallow capsules
- Unable to obtain informed consent
- Unable to comply with avoidance of honey and propolis containing foods (which interfere with the silybin assays for measurement of plasma concentrations)
Where it is running
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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