Nicotine Replacement Therapy (NRT) and Bupropion Mechanisms of Effectiveness in Smokers

Completed · Phase 4 · Has a placebo group

Conditions studied: Nicotine Dependence

In brief

The purpose of this study is to better characterize differences in mood, attention, brain activation patterns underlying the beneficial effects of pharmacological treatments previously demonstrated to be help individuals successfully quit tobacco smoking. Smokers will be randomly assigned to one of three treatments: 1) bupropion sustained release (SR), 2) nicotine patch, or 3) placebo patches plus pills across a 45-day period with a 3-week intensive post-treatment follow-up. In addition, 20 percent of the subjects will be randomized to a delayed-quit control group.

Key facts

Study ID

NCT01048944

Run by

Southern Illinois University Carbondale

People needed

197

Starts

2005-06-01

Expected to finish

2013-01-01

Last updated by the study team

2014-11-25

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• DSM-IV diagnosis of abuse or dependence on alcohol or drugs other than nicotine
• Current Axis I diagnosis or current treatment with psychotropic medications within the three months prior to enrollment
• History of schizophrenia or other psychotic disorders, bipolar disorder, or anxiety disorders
• Currently seeking treatment for nicotine disorders
• History of seizures or head trauma with loss of consciousness, brain contusion, or fracture
• History of significant recent violent behavior
• Blood pressure greater than 150/90
• History of eating disorders
• History of allergic reaction to any of the study medications
• Pregnant

Where it is running

• Southern Illinois University — Carbondale, Illinois, United States

Full record on ClinicalTrials.gov

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