Sevoflurane as an Anesthetic During Dilation and Evacuation Procedures
Completed · Phase 4
Conditions studied: Blood Loss, Anesthesia
In brief
Sevoflurane is an FDA-approved anesthetic drug commonly used for anesthesia during second trimester abortion procedures. It has a few advantages, including ease of use by the anesthesia provider. However, the literature suggests that when used in doses higher than those used at Oregon Health \& Science University (OHSU) and Lovejoy, it is associated with an increase in the risk of bleeding. The investigators study aims to test whether the lower dose used at OHSU and Lovejoy during second trimester abortion procedures causes any difference in blood loss, when compared to similar abortion procedures for which this drug is not used.
Key facts
- Study ID
- NCT01048658
- Run by
- Oregon Health and Science University
- People needed
- 160
- Starts
- 2009-09-01
- Expected to finish
- 2011-08-01
- Last updated by the study team
- 2017-08-09
Who can join
Age: 18 and older, up to 50. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Voluntarily requesting pregnancy termination
- Estimated gestational age of 18 weeks - 23 weeks, 6 days gestational age as calculated by fetal biparietal diameter on clinic ultrasound.
- Be able and willing to sign an informed consent and agree to terms of the study
You may not qualify if…
- Known severe maternal respiratory disease or upper respiratory infection or sinus blockage
- Anticoagulation use: within 24 hours if Lovenox, or within 12 hours if heparin, (Must have a documented normal international normalized ratio (INR) prior to procedure if on anticoagulation)
- Multiple pregnancy
- Fetal demise, if more than 2 weeks difference exists between known gestational age (by previous US dating) and gestational size on current ultrasound.
- Known allergy/sensitivity to sevoflurane or any other inhaled anesthetic agents
Where it is running
- Lovejoy Surgicenter — Portland, Oregon, United States
- Oregon Health and Sciences University — Portland, Oregon, United States
Full record on ClinicalTrials.gov
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