The Effect of Exercise on Acute Nicotine Withdrawal
Completed · Not applicable
Conditions studied: Nicotine Dependence, Smoking, Sleep Disorders, Intrinsic
In brief
The primary aim of this project is to test the effect of exercise on acute nicotine withdrawal. Acute nicotine withdrawal is characterized by a complex array of symptoms associated with increased risk of relapse among individuals attempting smoking cessation. The available remedies do not target all aspects of withdrawal. For example, pharmacologic treatments reduce withdrawal-based craving, but have no effect on cue-related craving, altered sleep, and mood disturbances during withdrawal. Therefore, non-pharmacologic behavioral techniques with the potential to attenuate persistent withdrawal symptoms are needed. We hypothesized that exercise can be a valid non-pharmacologic strategy to improve these domains.
Key facts
- Study ID
- NCT01047930
- Run by
- University of Pittsburgh
- People needed
- 88
- Starts
- 2010-01-01
- Expected to finish
- 2013-07-01
- Last updated by the study team
- 2014-12-02
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 18-45
- Not regularly exercising, defined as exercising fewer than three times per week and for no more than 20 minutes each time
- Free of medical illnesses (need to be cleared by a physician as able to exercise at 60% maximum heart rate (MHR))
- Currently meeting DSM-IV criteria for nicotine dependence (No Current or Past history of any other psychiatric disorder)
- Regularly smoking at least 08 cigarettes per day for at least 12 consecutive months, not attempted to quit smoking in the previous month, and not currently taking medication for smoking cessation
- Currently displaying carbon monoxide breath readings >10 and urine cotinine levels >3
- Habitual bedtime between 9:30 p.m. and 1:30 a.m.
- Body Mass Index (BMI) less than 40.
You may not qualify if…
- Unable to exercise
- Currently diagnosed or treated for any psychiatric disorder; treatment with psychotropic medication will be considered on a case by case basis
- History or active treatment or any treatment in past year for any mood or psychotic disorder
- Current or past diagnosis of a sleep disorder
- Currently taking sleep medications or other medications known to alter sleep architecture
- Currently doing shift work or working at night
- History of travel across time zones in the past month
- For women of child bearing potential: pregnant or actively trying to become pregnant
- Parent of a child under two years of age
- Diagnosis of Sleep Apnea
Where it is running
- University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
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