Early Menopause Hormone Treatment and Cognition

Completed · Not applicable · Has a placebo group

Conditions studied: Menopausal Syndrome

In brief

The objective of this study is to evaluate the neurobiological effects of hormone therapy (HT) in healthy early postmenopausal women. The studies proposed in this project seek to define the association between different hormone forms (estradiol only and progesterone only) versus placebo on brain functional measures. The functional measures will include the performance of the volunteers on a comprehensive neuropsychological testing battery, and the brain functional responses to episodic memory (verbal and non-verbal) challenges as well as emotional processing determined with functional magnetic resonance imaging (fMRI).

Key facts

Study ID

NCT01046643

Run by

University of Michigan

People needed

30

Starts

2010-05-01

Expected to finish

2012-03-01

Last updated by the study team

2014-05-19

Who can join

Age: 45 and older, up to 55. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Postmenopausal women
• Ages 45-55, 6 - 36 months from their last menstrual period.

You may not qualify if…

• Left handedness
• Acute medical illness
• Neurologic illness
• Psychiatric illness
• Heart disease
• Thromboembolic disease
• Liver disease
• Uncorrected thyroid disease
• Diabetes
• Neurological disease
• Porphyria
• Allergy to estradiol
• Progesterone or lactose
• Lactose intolerance
• Claustrophobia
• Contraindications to MRI (including pacemakers, surgical clips or metallic surgical devices)
• Smoking within the last 3 years
• Use of hormones within the last 3 months
• Current or past history of substance abuse
• History of head injury or loss of consciousness
• Medications with actions on the central nervous system
• Endometrial lining greater than 5mm
• Ovarian pathology on ultrasound
• Abnormal mammogram
• Migraines

Where it is running

• The University of Michigan — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.