A Study in Healthy Volunteers to Assess the Tolerability and Blood Levels of a Single Dose of AZD7687

Completed · Phase 1 · Has a placebo group

Conditions studied: Healthy

In brief

This is a Phase I, first time in human, randomised, blinded, placebo-controlled, single ascending dose study in healthy male volunteers conducted at a single centre. The effect of food on the pharmacokinetics of AZD7687 will also be studied. The study will consist of two parts, a dose escalation part and a food interaction part. The two parts will be run in parallel. In total, 64 healthy volunteers divided in 8 different panels (8 volunteers per cohort) will be exposed to single doses during the dose escalation. Each subject will receive dose only once, except for the volunteers included in the dose steps repeated for food interaction.

Key facts

Study ID

NCT01046357

Run by

AstraZeneca

People needed

64

Starts

2009-11-01

Expected to finish

2010-06-01

Last updated by the study team

2012-02-13

Who can join

Age: 20 and older, up to 45. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Healthy
• BMI between 19-30

You may not qualify if…

• No blood donation prior 30 days
• No other clinical study prior 3 months

Where it is running

• Research Site — Overland Park, Kansas, United States

Full record on ClinicalTrials.gov

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