Botulism Toxin Injection as a Treatment for Arthritis of the Basal Thumb Joint

Stopped early · Phase 4

Conditions studied: Arthritis Multiple Joint

In brief

Basal arthritis of the thumb is a common condition with increased prevalence in post-menopausal women, obese persons, and the elderly. Surgical options are varied and efficacious, but not all patients are candidates for surgery. The successes and pitfalls of previous, similar trials are carefully considered in the creation of our own. Though steroid injection is the standard of care in basal joint arthritis, current data does not support its efficacy beyond placebo effect. No trial has yet examined the efficacy of botulinum toxin type A (BTX-A) injection into the basal thumb joint nor compared it to steroid. Since efficacy of steroid is questionable at best, our hope is that BTX-A injection of the basal joint might be the next great tool in treating this common, debilitating disease.

Key facts

Study ID

NCT01045694

Run by

University of Missouri-Columbia

People needed

8

Starts

2011-03-01

Expected to finish

2015-10-01

Last updated by the study team

2017-10-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Radiographic evidence of basal joint arthritis
• Associated symptoms of basal joint arthritis including:
• Pain
• Decreased range of motion
• Decreased thumb strength

You may not qualify if…

• Persons under the age of 18
• Women who are currently pregnant
• Incompetent persons or persons otherwise incapable of effectively communicating the subjective experience of pain
• Prior surgery on the joint
• Injection in the last 12 months

Where it is running

• University of Missouri — Columbia, Missouri, United States

Full record on ClinicalTrials.gov

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