Levetiracetam and Memory Function in Amnestic Mild Cognitive Impairment (MCI)
Completed · Phase 2 · Has a placebo group
Conditions studied: Mild Cognitive Impairment (MCI)
In brief
This research is being done to find out if daily use of the drug levetiracetam can improve memory function in individuals with memory problems like those associated with Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD).
Key facts
- Study ID
- NCT01044758
- Run by
- Johns Hopkins University
- People needed
- 96
- Starts
- 2009-12-01
- Expected to finish
- 2012-07-01
- Last updated by the study team
- 2017-08-21
Who can join
Age: 50 and older, up to 85. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- All: English as a first language; right handed; able to complete written informed consent.
- MCI subjects: In addition to above, must meet criteria for amnestic Mild Cognitive Impairment (MCI). This includes a memory complaint corroborated by an informant; impaired memory function for age and educational level; preserved general cognitive function; intact abilities of daily living; no clinical dementia.
- Age matched Controls: Must have memory and cognitive status that is normal for their age.
You may not qualify if…
- Familial Alzheimer's Disease (AD) due to known genetic mutations
- AD with Parkinsonian features; major psychiatric or behavioral disorders (e.g. depression, agitation, psychosis, manic-depressive disorder)
- Primary or metastatic intracranial neoplasm
- History of severe head trauma
- Intra-cerebral hemorrhage
- Seizure disorder
- Hemispheric stroke
- Presence of a progressive central nervous system disease
- Presence of lacunar infarcts
- Medical contraindications to MRI including cardiac pacemaker, presence of intraocular or intracranial metallic objects
- Any known allergy to levetiracetam or behavioral problems that are a contraindication to taking Levetiracetam (e.g. agitation)
- Prescribed use of anti-seizure medications.
Where it is running
- Johns Hopkins University School of Medicine — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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