Maternal Oxygen Use During Delivery and Cord Blood Superoxide Dismutase

Completed · Not applicable · Has a placebo group

Conditions studied: Oxidative Stress, Fetal Distress

In brief

When exposed to oxygen immediately after birth, newborns suffer from an oxidative stress with a significant decrease in serum concentration of the anti-oxidant enzyme superoxide dismutase. This oxidative stress has been consequently linked to the development of adverse outcomes in both premature and full term infants. In this study, we examined the effect of oxygen administration to delivering mothers immediately before and during labor on the newborn. In this randomized trial, we planned to measure superoxide dismutase in the umbilical cord blood when mothers received and did not receive oxygen..

Key facts

Study ID

NCT01042262

Run by

George Washington University

People needed

60

Starts

2007-02-01

Expected to finish

2009-08-01

Last updated by the study team

2010-01-05

Who can join

Age: any. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• uncomplicated pregnancy
• term gestational age from completed 37 weeks to 42 weeks, and
• normal spontaneous vaginal delivery or elective caesarean section

You may not qualify if…

• hypertension, or eclampsia
• diabetes
• anemia
• other medical or surgical complications during the current pregnancy
• rupture of amniotic membranes for more than 18 hours
• history of infants with invasive group B Streptococcal disease in previous pregnancies
• fetal distress before delivery, and
• suspected chromosomal, and structural anomalies or congenital infections

Where it is running

• The George Washington University Hospital — Washington D.C., District of Columbia, United States

Full record on ClinicalTrials.gov

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