Gemcitabine Hydrochloride or Pemetrexed Disodium and Carboplatin With or Without Celecoxib in Treating Patients With Advanced Non-Small Cell Lung Cancer

Stopped early · Phase 3 · Has a placebo group

Conditions studied: Lung Cancer

In brief

RATIONALE: Drugs used in chemotherapy, such as gemcitabine hydrochloride and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Pemetrexed disodium and celecoxib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether giving gemcitabine hydrochloride or pemetrexed disodium together with carboplatin is more effective with or without celecoxib in treating non-small cell lung cancer. PURPOSE: This randomized phase III trial is studying gemcitabine hydrochloride, pemetrexed disodium, and carboplatin to compare how well they work when given together with celecoxib or a placebo in treating patients with advanced non-small cell lung cancer.

Key facts

Study ID

NCT01041781

Run by

Alliance for Clinical Trials in Oncology

People needed

313

Starts

2010-02-01

Expected to finish

2018-03-01

Last updated by the study team

2018-07-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Mayo Clinic Scottsdale — Scottsdale, Arizona, United States
• NEA Medical Clinic - East Matthews — Jonesboro, Arkansas, United States
• Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• City of Hope Comprehensive Cancer Center — Duarte, California, United States
• Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
• Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center — Los Angeles, California, United States
• Camino Medical Group - Treatment Center — Mountain View, California, United States
• Palo Alto Medical Foundation-Camino Division — Mountain View, California, United States
• Palo Alto Medical Foundation — Palo Alto, California, United States
• Feather River Hospital Cancer Center — Paradise, California, United States
• PCR Oncology — Pismo Beach, California, United States
• Naval Medical Center - San Diego — San Diego, California, United States
• UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States
• Veterans Affairs Medical Center - San Francisco — San Francisco, California, United States
• Poudre Valley Hospital — Fort Collins, Colorado, United States
• Front Range Cancer Specialists — Fort Collins, Colorado, United States
• Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center — Hartford, Connecticut, United States
• Middlesex Hospital Cancer Center — Middletown, Connecticut, United States
• Tunnell Cancer Center at Beebe Medical Center — Lewes, Delaware, United States
• CCOP - Christiana Care Health Services — Newark, Delaware, United States
• Washington Cancer Institute at Washington Hospital Center — Washington D.C., District of Columbia, United States
• Veterans Affairs Medical Center - Washington, DC — Washington D.C., District of Columbia, United States
• North Broward Medical Center — Deerfield Beach, Florida, United States
• Florida Hospital - Orlando — Orlando, Florida, United States
• Regional Medical Center — Anniston, Alabama, United States

Full record on ClinicalTrials.gov

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