Vascular Function, Insulin Sensitivity, and Vitamin D
Completed
Conditions studied: Insulin Sensitivity, Flow-mediated Dilation, Arterial Stiffness
In brief
The overall objectives of this study are to examine the relationships between circulating vitamin D, insulin sensitivity, and multiple indices of vascular function and to examine whether vitamin D deficiency in African Americans (AA) and White Hispanics (WH) is responsible for ethnic differences in insulin sensitivity and hypertension in AA, WH and European Americans (EA), as well as mechanisms underlying the association between insulin resistance and blood pressure. We hypothesize that 1) serum 25(OH)D is associated with insulin sensitivity and vascular functioning, independent of adiposity, 2) lower insulin sensitivity and vascular functioning in AA and WH relative to EA is due to lower circulating 25(OH)D in AA, and 3) the relationship between insulin resistance and vascular dysfunction is mediated by 25(OH)D. Acronyms: African American (AA), European American (EA), White Hispanics (WH), Serum 25-hydroxy vitamin D (25()H)D, Body mass index (BMI), Alabama (AL).
Key facts
- Study ID
- NCT01041547
- Run by
- University of Alabama at Birmingham
- People needed
- 63
- Starts
- 2009-12-01
- Expected to finish
- 2013-12-01
- Last updated by the study team
- 2014-01-14
Who can join
Age: 19 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- African American (AA), White Hispanic (WH), and European American (EA) race
- Ages 19-60 years
- Negative urine pregnancy test
- No evidence of diabetes
- Not on medications that can affect vascular functioning or insulin sensitivity
You may not qualify if…
- BMI > 32 kg/m2
- Diabetes or any chronic diseases
- Use of medication(s) known to influence body composition, vascular function, or glucose metabolism
- Regular smoking
- Regular use of illegal drugs and pregnancy
Where it is running
- University of Alabama — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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