Vitamin D, Insulin Sensitivity, and Vascular Associations in Adolescents

Completed

Conditions studied: Insulin Sensitivity, Flow-mediated Dilation, Arterial Stiffness

In brief

The overall objectives of this study are to examine the relationships between circulating vitamin D, insulin sensitivity, and multiple indices of vascular function and to examine whether vitamin D deficiency in AA is responsible for ethnic differences in insulin sensitivity and hypertension in AA and EA, as well as mechanisms underlying the association between insulin resistance and blood pressure. We hypothesize that 1) serum 25(OH)D is associated with insulin sensitivity and vascular functioning, independent of adiposity, 2) lower insulin sensitivity and vascular functioning in AA relative to EA is due to lower circulating 25(OH)D in AA, and 3) the relationship between insulin resistance and vascular dysfunction is mediated by 25(OH)D. Acronyms: African American (AA), European American (EA), Serum 25-hydroxy vitamin D (25()H)D, Body mass index (BMI), Alabama (AL).

Key facts

Study ID

NCT01041365

Run by

University of Alabama at Birmingham

People needed

62

Starts

2009-12-01

Expected to finish

2013-12-01

Last updated by the study team

2014-01-14

Who can join

Age: 14 and older, up to 18. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• African American or Caucasian ethnicity
• Ages 14-18 yrs
• Healthy

You may not qualify if…

• BMI-for age and -sex higher than 95th centile on the Centers for Disease Control and Prevention Growth Charts
• Use of medication(s) known to influence body composition, vascular function, or glucose metabolism
• Pregnancy
• Diabetes or any chronic diseases

Where it is running

• University of Alabama — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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