DECIFER: Depression and Citalopram In First Episode Recovery

Completed · Phase 4 · Has a placebo group

Conditions studied: Schizophrenia, Schizophreniform Disorder

In brief

This study seeks to examine the effectiveness of citalopram added to treatment with any oral or injectable second-generation antipsychotic plus standardized psychoeducation in first episode schizophrenia patients. Because depressive symptoms are common in first episode patients, we will test the hypothesis that adding the SSRI citalopram to a pre-established medication regimen will improve quality of life and decrease relapse and suicidality over the course of a 12-month trial.

Key facts

Study ID

NCT01041274

Run by

NYU Langone Health

People needed

95

Starts

2010-01-01

Expected to finish

2018-03-26

Last updated by the study team

2019-12-17

Who can join

Age: 16 and older, up to 40. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female
• Ages 16-40 years
• Schizophrenia, any subtype or Schizophreniform disorder
• Treated with any of the following second generation antipsychotics for at least 4 weeks and fewer than 16 weeks: risperidone, olanzapine, quetiapine, aripiprazole, ziprasidone, or paliperidone)
• Willing to participate in psychoeducation
• Sufficient proficiency in English to complete assessments

You may not qualify if…

• Major depression by DSM-IV criteria
• Clinical Global Assessment of Severity of Suicidality of 3 (moderate) or greater.
• Calgary Depression Scale for Schizophrenia (CDRS) score of 7 or greater
• Serious suicide attempt within three years or ANY suicide attempt for subjects age 16-25.
• Current treatment with an MAOI or pimozide
• Active alcohol or other substance abuse or dependence within three months
• Unstable medical illness
• History of SSRI intolerance
• Pregnant or nursing
• QTc ≥ 500 msec

Where it is running

• New York University Langone Medical Center/ Bellevue Hospital — New York, New York, United States

Full record on ClinicalTrials.gov

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