Frozen Red Blood Cell Transfusions in Trauma Patients

Completed · Not applicable

Conditions studied: Blood Loss, Anemia, Trauma

In brief

The purpose of this study is to look at red blood cell (RBC) transfusions in trauma patients and evaluate for any differences between the age of the RBCs and how they were stored. The investigators will specifically look for the following differences between study groups: 1. the transfused red blood cells' ability to delivery oxygen to the tissues 2. differences in biochemical markers in subjects and units transfused, and 3. how the subject's internal organs are working and if they develop any infections

Key facts

Study ID

NCT01038557

Run by

Oregon Health and Science University

People needed

254

Starts

2010-01-01

Expected to finish

2014-05-01

Last updated by the study team

2020-01-28

Who can join

Age: 15 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Trauma Service with an Injury Severity Score > 4
• Require a blood (PRBC) transfusion
• Transfusion is not emergent
• Able to obtain consent from patient or appropriate 3rd party prior to 1st transfusion

You may not qualify if…

• Inability to adhere to blood age randomization due to limitations of the blood bank inventory
• Bilateral hand injuries that prevent StO2 measurements
• Age < 15
• Pregnancy
• Massive transfusion (=/> 10 units in 24 hours) in last 3 months
• Hemodynamically unstable or need for transfusion in < 3 hours

Where it is running

• University of Cincinnati — Cincinnati, Ohio, United States
• Oregon Health & Science University — Portland, Oregon, United States
• University of Texas Southwestern Medical Center — Dallas, Texas, United States
• University of Texas Health Science Center at Houston — Houston, Texas, United States
• University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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