Exercise in Obese Diabetic Patients With Chronic Kidney Disease

Completed · Not applicable

Conditions studied: Chronic Kidney Disease

In brief

Patients with type 2 diabetes, obesity, and chronic kidney disease are generally physically inactive, have a high mortality rate, and may benefit from an exercise program. This study seeks to determine if a structured exercise program will benefit the heart (improved exercise tolerance, decreased blood pressure) and/or the kidney (decreased protein loss in urine and stabilization of kidney function) and lead to improvements in diabetes, body composition, and quality of life.

Key facts

Study ID

NCT01036490

Run by

VA Office of Research and Development

People needed

36

Starts

2010-07-01

Expected to finish

2017-06-30

Last updated by the study team

2018-07-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diabetes mellitus
• CKD Stages 2-4
• BMI > 30
• Persistent proteinuria (urine protein/creatinine > 200 mg/g for > 3 mo)
• On treatment with ACE inhibitor or ARB
• On treatment with aspirin
• On treatment with statin (if LDL > 100)

You may not qualify if…

• Symptomatic neuropathy/retinopathy
• Positive stress test due to coronary arterial disease
• Symptomatic cardiovascular disease
• Congestive heart failure (New York Heart Association Class III or IV)
• Chronic obstructive pulmonary disease (FEV1 < 50% predicted and/or requires supplemental oxygen support during exercise)
• Complaints of angina during the stress test
• Cerebrovascular disease/cognitive impairment
• Renal transplant
• Inability to walk on the treadmill
• Any unforeseen illness or disability that would preclude exercise testing or training
• Participation in a formal exercise program within the previous 12 weeks

Where it is running

• Edward Hines Jr. VA Hospital, Hines, IL — Hines, Illinois, United States

Full record on ClinicalTrials.gov

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