Chlorhexidine Gel Therapy for Cariogenic Oral Microflora

Completed · Phase 1

Conditions studied: Head and Neck Cancer

In brief

The goal of this clinical research study is to find out if 1% chlorhexidine gluconate gel will decrease the amount of bacteria that causes tooth decay. Whether the gel is acceptable to patients will also be studied.

Key facts

Study ID: NCT01036412
Run by: M.D. Anderson Cancer Center
People needed: 4
Starts: 2009-12-01
Expected to finish: 2012-08-01
Last updated by the study team: 2016-02-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Inclusion:
Patients who have undergone radiation treatment to the head and neck at U.T. M. D. Anderson Cancer Center for oral cavity or oropharyngeal cancer (base of tongue and tonsil) and have recent documented caries, within 8 weeks, on routine oral examination.
Patients with >/= 10 teeth.
Patients with >/= 100,000 CFU/ ml S. mutans in the baseline microbiological sample (i.e., supragingival curette sampling).

You may not qualify if…

Patients using antibiotics in the past 4 weeks. (Note: A subject may have antibiotics administered during the study evaluation period, for unforeseen medical reasons. The patients will not be removed from the study and the plaque samples will be evaluated for descriptive assessment with the concomitant medication(s) recorded to determine if changes between the subject's samples were globally outside the range of changes for the population as a whole.)
Patients using chlorhexidine gluconate or antimicrobial rinses in past 2 weeks.
Patients under the age of 18.
Patients unable to return to dental clinic over the 20-week study period.
Patients with a known allergy to Chlorhexidine.

Where it is running

UT MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.