Effect of Functional Genetic Polymorphisms on Brain Morphology and Function
Completed
Conditions studied: Drug Abuse
In brief
Background: \- New research on genetics and the human genome has helped to identify certain genes that affect specific parts of the brain, including the parts that may be involved in drug use and dependency. Researchers are interested in studying both genetic information and brain activity to better understand variations in brain function among individuals. Objectives: \- To study brain activity in conjunction with specific genetic information provided by healthy volunteers including smokers, non-smokers, people with drug dependence, and those who do not have any dependence on any substance. Eligibility: \- Healthy volunteers between 18 and 50 years of age. Design: * This is an 8 10 hour study which may be completed in 1, 2, or 3 visits. * Participants will complete questionnaires about emotional and psychological responses to different situations, including stressful situations. * Participants will have a training session in a mock (fake) scanner to practice tasks to be completed in the real scanner. * Participants will have the following two types of magnetic resonance imaging (MRI) scans in one scan session of the brain: * A structural MRI scan to provide basic information about each participant's brain. * A functional MRI scanning session, in which participants will perform a memory task to provide information about brain activity. * Participants will provide blood samples for research and testing....
Key facts
- Study ID
- NCT01035723
- Run by
- National Institute on Drug Abuse (NIDA)
- People needed
- 221
- Starts
- 2005-09-13
- Expected to finish
- 2013-02-25
- Last updated by the study team
- 2019-12-16
Who can join
Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Subjects will be excluded if they:
- Are not suitable to undergo an MRI experiment due to pregnancy, implanted metallic devices (cardiac pacemaker or neurostimulator, some artificial joints, metal pins, surgical clips, or other implanted metal parts), body morphology, or claustrophobia.
- Have coagulopathies, history of or current superficial or deep vein thrombosis, musculoskeletal abnormalities restricting an individual s ability to lie flat for an extended period of time.
- Have HIV or syphilis.
- Have a neurological illness to include, but not limited to, seizure disorders, migraine, multiple sclerosis, movement disorders, or history of head trauma, CVA, CNS tumor.
- Have any current AXIS I psychiatric disorders including Attention Deficit Disorder (ADD). Have regular use of any prescription, over-the-counter, or herbal medication that may alter CNS function, cardiovascular function or neuronal-vascular coupling.
- Have current dependence on any substance other than cocaine, marijuana, or nicotine.
- Are cognitively impaired or are learning disabled.
Where it is running
- National Institute on Drug Abuse — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.