Longitudinal Impact of Adjuvant Chemotherapy on Functional Status, Comorbidity and Quality of Life

Running, not enrolling

Conditions studied: Breast Cancer

In brief

The goal of this study is to increase our understanding of the adjuvant chemotherapy experience in older and younger adults by prospectively describing the longitudinal trajectory of functional status, comorbidity, and quality of life from before the initiation of chemotherapy to 6 months after the completion of treatment in older (65 and older) and younger (under 65) adults. In addition, we will determine the effect of pre-treatment physical functioning on physical recovery after the course of adjuvant chemotherapy. The secondary objective of this study is to explore if factors other than chronological age (functional status, co-morbid medical conditions, nutritional status, psychological state, cognitive function, and social support) predicts which patients are more likely to experience morbidity (defined as grade 3-5 toxicity, hospitalization, dose reduction or delay, or premature discontinuation of chemotherapy course) from adjuvant chemotherapy.

Key facts

Study ID

NCT01030250

Run by

City of Hope Medical Center

People needed

238

Starts

2009-06-11

Expected to finish

2027-02-05

Last updated by the study team

2026-03-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with stages I-III breast cancer receiving adjuvant chemotherapy
• Able to understand English
• Able to provide informed consent
• Patients of any age and performance status are eligible

Where it is running

• City of Hope — Duarte, California, United States

Full record on ClinicalTrials.gov

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