Effects of Transcranial Magnetic Stimulation (TMS) and Stimulus Controllability on Pain Perception

Completed · Not applicable · Has a placebo group

Conditions studied: Chronic Pain

In brief

Although transcranial magnetic stimulation (TMS) is now considered a minimal risk intervention, is approved for the treatment of depression, and is widely used around the world, little is known about mechanisms of action of prefrontal rTMS for depression or pain. There is some evidence that the prefrontal cortex is involved in perception of control and may moderate the effects of perceived controllability on emotional reactivity to painful stimuli. The present study aims to investigate the effects of prefrontal rTMS and perceived controllability on pain perception in healthy adults.

Key facts

Study ID

NCT01030133

Run by

Medical University of South Carolina

People needed

28

Starts

2009-10-01

Expected to finish

2010-02-01

Last updated by the study team

2018-09-28

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-75 years of age

You may not qualify if…

• history of seizures or epilepsy
• family history of seizures
• history of chronic pain conditions
• current depression
• anxiety disorders
• taking any medications shown to lower seizure threshold
• metal implants above the waist
• pregnant
• brain tumors or lesions
• pacemaker

Where it is running

• Brain Stimulation Laboratory, Institute of Psychiatry — Charleston, South Carolina, United States

Full record on ClinicalTrials.gov

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