Medication Effects on Periurethral Sensation,Urethral Sphincter Activity and Pressure Flow Parameters
Completed · Not applicable
Conditions studied: Urethral Sphincter Activity
In brief
Lower urinary tract symptoms such as urinary leakage and overactive bladder affect millions of American women. Women may develop these problems because the innervation of the muscles of the bladder and urethra are injured. Most research on treating these problems has focused on the abnormalities of the bladder muscle, but newer studies have shown abnormalities in the innervation and muscle function of the urethra. Women with these symptoms may benefit from treatment with medications to improve their urethral function. However, to truly understand what types of medications will help women with these symptoms, the investigators wish to study how these medications affect innervation and muscle function in healthy women who do not have lower urinary tract symptoms.
Key facts
- Study ID
- NCT01028014
- Run by
- University of Alabama at Birmingham
- People needed
- 56
- Starts
- 2010-04-01
- Expected to finish
- 2011-04-01
- Last updated by the study team
- 2012-06-08
Who can join
Age: 19 and older, up to 51. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Healthy Females only
- Ages 19-51 and up including pre-menopausal older women who have had a normal menstrual cycle for the prior 3 months
- Able to take oral medication for 2 weeks
- For women of child bearing potential,willing to use an approved method of birth control during the study
You may not qualify if…
- Urinary Incontinence or other bladder symptoms
- Known neurologic disease that may impair urethral tone or sensation
- Currently taking a class of medication that is being tested (alpha-antagonists, anticholinergics, sympathomimetics, tricyclic antidepressants, or skeletal muscle relaxants)
- History of QTc prolongation or cardiac arrhythmia
- Pregnant, breastfeeding, or are less than 6 months postpartum
- Known hypersensitivity to or other contraindications to taking any of the study medications
Where it is running
- University of Alabama at Birmingham, The Kirklin Clinic — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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