Effect of Montelukast Therapy in Obstructive Sleep Apnea(OSA) Children
Stopped early · Phase 4 · Has a placebo group
Conditions studied: Obstructive Sleep Apnea
In brief
The investigators leading hypotheses are: * Oral therapy with montelukast may lead to improved sleep study findings in children with mild to moderate Obstructive Sleep Apnea Syndrome (OSAS) who require surgical removal of adenoids and tonsils for OSAS. * A significant proportion of the children with OSAS treated with montelukast will show reduced severity of OSAS, and this will remove the need for surgical intervention.
Key facts
- Study ID
- NCT01027806
- Run by
- University of Chicago
- People needed
- 64
- Starts
- 2010-07-01
- Expected to finish
- 2014-08-01
- Last updated by the study team
- 2019-05-03
Who can join
Age: 2 and older, up to 10. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Eligible for inclusion in the study will be symptomatic snoring children >2 years of age and < 10 years of age, who snore and have an apnea hypopnea index (AHI) >2/hrTST (hour total sleep time), and in whom T\&A is therefore contemplated. Also among these, we will include children referred for evaluation for snoring who have a history of allergic rhinitis.
You may not qualify if…
- Exclusion criteria will include: Hypersensitivity to montelukast, immunodeficiency or immunosuppressant therapy, craniofacial, neuromuscular, syndromic or defined genetic abnormalities, acute upper respiratory tract infection, systemic corticosteroid therapy or antibiotic therapy in the 2 weeks previous to the study, and children who already had adenotonsillectomy. In addition, children chronically receiving oral antihistamine preparations or nasal decongestants will be required to continue using these medications throughout the duration of the study. Patients receiving immunotherapy will continue on the same regimen without escalation of dose and frequency throughout the duration of the study. In addition, patients with severe OSA who in the opinion of their treating physicians require early surgical intervention for their OSA will be excluded from eligibility to the study.
Where it is running
- University of Chicago — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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