Donor Stem Cell Transplant in Treating Patients With High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Completed · Phase 2
Conditions studied: Leukemia, Lymphoma
In brief
RATIONALE: Giving low doses of chemotherapy before a donor stem cell transplant helps stop the growth of cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. Also, monoclonal antibodies, such as rituximab, can find cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. The donated stem cells may replace the patient's immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving tacrolimus, sirolimus, and methotrexate after the transplant may stop this from happening. PURPOSE: This phase II trial is studying how well donor stem cell transplant works in treating patients with high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma.
Key facts
- Study ID
- NCT01027000
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 68
- Starts
- 2010-02-01
- Expected to finish
- 2023-04-01
- Last updated by the study team
- 2023-05-06
Who can join
Age: 18 and older, up to 69. Sex: any. Healthy volunteers: not accepted.
Where it is running
- City of Hope Comprehensive Cancer Center — Duarte, California, United States
- Tunnell Cancer Center at Beebe Medical Center — Lewes, Delaware, United States
- CCOP - Christiana Care Health Services — Newark, Delaware, United States
- Florida Hospital Cancer Institute at Florida Hospital Orlando — Orlando, Florida, United States
- H. Lee Moffitt Cancer Center and Research Institute at University of South Florida — Tampa, Florida, United States
- University of Chicago Cancer Research Center — Chicago, Illinois, United States
- Holden Comprehensive Cancer Center at University of Iowa — Iowa City, Iowa, United States
- Union Hospital of Cecil County — Elkton, Maryland, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Dana-Farber/Brigham and Women's Cancer Center — Boston, Massachusetts, United States
- Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis — St Louis, Missouri, United States
- UNMC Eppley Cancer Center at the University of Nebraska Medical Center — Omaha, Nebraska, United States
- Cancer Institute of New Jersey at Cooper - Voorhees — Voorhees Township, New Jersey, United States
- Roswell Park Cancer Institute — Buffalo, New York, United States
- Monter Cancer Center of the North Shore-LIJ Health System — Lake Success, New York, United States
- CCOP - North Shore University Hospital — Manhasset, New York, United States
- Don Monti Comprehensive Cancer Center at North Shore University Hospital — Manhasset, New York, United States
- Long Island Jewish Medical Center — New Hyde Park, New York, United States
- New York Weill Cornell Cancer Center at Cornell University — New York, New York, United States
- Memorial Sloan-Kettering Cancer Center — New York, New York, United States
- Wake Forest University Comprehensive Cancer Center — Winston-Salem, North Carolina, United States
- Cleveland Clinic Taussig Cancer Center — Cleveland, Ohio, United States
- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
- Oklahoma University Cancer Institute — Oklahoma City, Oklahoma, United States
Full record on ClinicalTrials.gov
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