Veliparib and Temozolomide in Treating Patients With Recurrent Glioblastoma
Completed · Phase 1/Phase 2
Conditions studied: Brain and Central Nervous System Tumors
In brief
RATIONALE: Veliparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as temozolomide. work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving veliparib together with temozolomide may kill more tumor cells. PURPOSE: This randomized phase I/II trial is studying the side effects and best dose of giving veliparib together with temozolomide and to see how well it works in treating patients with recurrent glioblastoma.
Key facts
- Study ID
- NCT01026493
- Run by
- Radiation Therapy Oncology Group
- People needed
- 257
- Starts
- 2010-07-01
- Expected to finish
- 2016-12-01
- Last updated by the study team
- 2017-07-02
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
- Cedars-Sinai Medical Center — Los Angeles, California, United States
- Cancer Research Center of Hawaii — Honolulu, Hawaii, United States
- Queen's Cancer Institute at Queen's Medical Center — Honolulu, Hawaii, United States
- Hawaii Medical Center - East — Honolulu, Hawaii, United States
- Leeward Radiation Oncology — ‘Ewa Beach, Hawaii, United States
- University of Chicago Cancer Research Center — Chicago, Illinois, United States
- CCOP - Kansas City — Prairie Village, Kansas, United States
- Central Baptist Hospital — Lexington, Kentucky, United States
- Louisville Oncology at Norton Cancer Institute - Louisville — Louisville, Kentucky, United States
- Regional Cancer Center at Singing River Hospital — Pascagoula, Mississippi, United States
- Renown Institute for Cancer at Renown Regional Medical Center — Reno, Nevada, United States
- Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire, United States
- Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School — New Brunswick, New Jersey, United States
- Highland Hospital of Rochester — Rochester, New York, United States
- James P. Wilmot Cancer Center at University of Rochester Medical Center — Rochester, New York, United States
- Legacy Good Samaritan Hospital & Comprehensive Cancer Center — Portland, Oregon, United States
Full record on ClinicalTrials.gov
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