Cell Bound Complement Activation Proteins as Markers of Liver Injury
Withdrawn before enrolling
Conditions studied: Hepatitis C
In brief
Subjects who eventually undergo treatment for HCV, we will gather treatment data (start and stop dates), and repeat CB-CAP analysis at weeks 4, 12, 24 and 72 (+/- 2 week window allowed at each time point) to determine whether CB-CAPs levels predict virologic response in treated subjects. Routine laboratory data will also be collected at these time points.
Key facts
- Study ID
- NCT01025531
- Run by
- University of Pittsburgh
- People needed
- 0
- Starts
- 2008-12-01
- Expected to finish
- 2014-12-01
- Last updated by the study team
- 2014-12-08
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 years of age or older at time of evaluation
- Able to give informed consent
- Confirmed HCV infection by standard antibody testing any time prior to enrollment
- Detectable HCV RNA in routine clinical testing any time prior to enrolment (since our aim is to determine the correlation between CB-CAPs and histologic activity in chronic HCV)
- Undergoing liver biopsy as part of their routine clinical care
You may not qualify if…
- Any previous treatment for HCV
- Any other chronic or active liver disease that, in the opinion of the investigator, can affect liver histology (history of alcohol use in itself will not be an exclusion criteria)
- HIV coinfection
- Chronic Hepatitis B infection (HBsAg+ or HBeAg+ or HBV DNA+ upon last testing)
- Acute Hepatitis A infection (HAV IgM+ upon last testing)
- Use of medications that may cause increase in serum aminotransferase levels (e.g. HMG co-A reductase inhibitors, anti-epileptics, etc.) within 30 days prior to enrollment
- Any chronic or active inflammatory disease that may potentially be associated with higher inflammatory markers (examples include, but not limited to: tuberculosis, inflammatory bowel disease, pneumonia, autoimmune disease)
Where it is running
- UPMC — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.