Comparison of Transdermal and Oral Estrogens in Adolescent Girls With Ovarian Failure

Completed · Not applicable

Conditions studied: Ovarian Failure, Premature

In brief

To directly compare the safety (by laboratory evaluation) and efficacy (feminization and growth) of three commonly used estrogen preparations in adolescent patients with ovarian failure, either due to congenital causes (Turner syndrome) or medical therapies. We hypothesize that transdermal estrogen will have equivalent efficacy and a more favorable safety profile in comparison with conventional oral estrogen replacement.

Key facts

Study ID

NCT01023178

Run by

Stanford University

People needed

20

Starts

2007-02-01

Expected to finish

2013-06-01

Last updated by the study team

2017-01-20

Who can join

Age: 12 and older, up to 18. Sex: female. Healthy volunteers: not accepted.

You may not qualify if…

• spontaneous menses
• significant concurrent medical problem including:
• Liver function tests (LFTs) 3 times normal
• clotting disorder
• ongoing cancer treatment

Where it is running

• Stanford University School of Medicine — Stanford, California, United States

Full record on ClinicalTrials.gov

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