Effects of Training on Central Auditory Function in Multiple Sclerosis

Completed · Not applicable

Conditions studied: Multiple Sclerosis

In brief

The purpose of this study is to characterize the central auditory processing (CAP) deficits that result from multiple sclerosis (MS).

Key facts

Study ID

NCT01023074

Run by

VA Office of Research and Development

People needed

52

Starts

2007-10-01

Expected to finish

2011-06-01

Last updated by the study team

2018-10-09

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• age 21-65 years;
• a clinical or laboratory supported diagnosis of "definite" MS;
• a diagnosis of relapsing-remitting, primary progressive, or secondary progressive MS;
• a Kurtzke Expanded Disability Status Score (EDSS) of 0 to 7.0, inclusive;
• no history of a clinical relapse or change in EDSS for three months preceding entry into the study; and
• a brain MRI scan that shows at least three white-matter lesions on T2-weighted images consistent with MS

You may not qualify if…

• current major disease or disorder other than MS (e.g., cancer, end-stage renal disease, end-stage cardiopulmonary disease, post-traumatic stress disorder, diabetes);
• other neurological conditions that could interfere with the ability to respond to tests and questionnaires;
• non-native speaker of English (since test materials are presented in English);
• pregnant (due to potential negative effects on the fetus during fMRI);
• more than a mild degree (less than a 40 dB HL four-frequency pure-tone average [PTA]) of hearing loss bilaterally (since the presence of more than a mild degree of peripheral hearing impairment may impact CAP test results);
• metal implants (due to fMRI constraints); and
• left-handedness

Where it is running

• VA Portland Health Care System, Portland, OR — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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