Prospective Study Evaluating the Effect of Repository Corticotropin in the Treatment of Various Nephrotic Syndromes

Completed · Phase 4

Conditions studied: Nephrotic Syndromes

In brief

To determine if H.P. Acthar Gel (repository corticotrophin) has the same anti-proteinuric effects seen with the synthetic ACTH analogue in Europe.

Key facts

Study ID

NCT01021540

Run by

Arizona Kidney Disease and Hypertension Center

People needed

18

Starts

2009-12-01

Expected to finish

2010-10-01

Last updated by the study team

2011-07-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Nephrotic Syndrome with a minimal of 3.5grams of protein per 24 hr period, measured via either 24hr urine collection or spot protein to creatinine ratio.
• Males and post-menopausal, surgically sterile, or non-lactating and non-pregnant females using adequate contraception
• Biopsy proven diagnosis of nephrotic syndrome due to Lupus glomerulonephritis, Membranous nephropathy, Focal segmental glomerulosclerosis, Minimal Change disease, Diabetic nephropathy (type 2)or IgA nephropathy.
• Greater than 18 years of age
• Willing and able to give informed consent
• Diabetics are on insulin or willing to start insulin during the study

You may not qualify if…

• Previous intolerance to native ACTH or proteins of porcine origin
• History of scleroderma, osteoporosis, systemic fungal infections, ocular herpes simplex, recent surgery, history of or the presence of peptic ulcer, primary adrenocortical insufficiency or adrenocortical hyperfunction.
• Expected to begin renal replacement therapy or receive a transplant within the next year.
• Recent cardiovascular event within 3 months of screening including: Myocardial Infarction, CVA, TIA, New York Heart Association Functional Class III or IV failure, Obstructive valvular heart disease, or hypertrophic cardiomyopathy, second or third degree atrioventricular block not successfully treated with a pacemaker.
• History of HIV
• Know peptic ulcer disease.
• SBP> 160 or DBP > 100 at time of enrollment
• New diagnosis of cancer or recurrent cancer within 2 years of screening
• History of alcohol or drug abuse within 12 months of study entry.
• Receipt of any investigational drug within 30 days of enrollment.
• Anticipated major surgery during trial period
• Psychiatric disorder that interferes with the patient's ability to comply with the protocol.
• Inability to cooperate with study personnel or history of noncompliance to medical management
• Active infection within 1 month of screening
• Poorly controlled diabetes with an HbA1C > 10%
• Type 1 diabetes mellitus

Where it is running

• AKDHC — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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