Acute Respiratory Infection Consortium

Status unconfirmed

Conditions studied: Influenza

In brief

Recently, the emergence and rapid global dissemination of novel swine-origin influenza A virus (H1N1) with unique epidemiologic characteristics has heightened awareness and concern of this viral pathogen, and its potential for major disruption of both civil and military stability. Although advances in medical and scientific technologies have improved our basic understanding of respiratory disease, many questions about the epidemiology and immunology of ARI remain unanswered. This study plans to initiate a multi-site, multi-disciplinary research collaboration, termed the Acute Respiratory Infection Consortium (ARIC) for the purpose of studying the etiology, epidemiology and immunology of influenza-like illness (ILI) in order to describe the natural history and risk factors for disease, as well as the characteristics of the host immune response. At the core of the ARIC is the proposed observational, longitudinal study of the Natural History Study of ILI among active duty military members, healthy retirees, and their dependents recruited from both inpatient and outpatient settings of military treatment facilities (MTF) in the continental US to be followed for a total of four (4) visits over a 28-day period. Additionally, the investigators also propose to conduct a household-based study of influenza (Family Transmission Study) in which individuals who have a laboratory-confirmed influenza illness will be recruited and enrolled along with their family members for the purpose of studying transmission of influenza within households. Taken together, these studies will establish a longitudinal cohort of ILI among active duty members and their families, as well as a repository of biological specimens relevant to the epidemiology and immunology of infection. Ultimately, these studies will serve as a solid foundation on which future investigations of ARI epidemiology, treatment and prevention can be based.

Key facts

Study ID

NCT01021098

Run by

Henry M. Jackson Foundation for the Advancement of Military Medicine

People needed

2018

Starts

2009-11-01

Expected to finish

2023-12-01

Last updated by the study team

2023-11-24

Who can join

Age: 17 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Between 18 and 55 years of age (inclusive), or a 17 year old military service member
• Eligible for care in Department of Defense (DOD) facilities (DEERS eligible).
• Have an acute influenza-like illness (ILI) or severe acute respiratory infection (SARI) for </= 7 days

You may not qualify if…

• None

Where it is running

• Naval Medical Center, San Diego, CA — San Diego, California, United States
• Walter Reed National Military Medical Center — Bethesda, Maryland, United States
• San Antonio Military Medical Center/Wilford Hall — San Antonio, Texas, United States
• Naval Medical Center, Portsmouth, VA — Portsmouth, Virginia, United States
• Madigan Army Medical Center (MAMC) — Tacoma, Washington, United States

Full record on ClinicalTrials.gov

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