Prenatal Drug Exposure: Effects on the Adolescent Brain and Behavior Development
Completed
Conditions studied: Drug Abuse, Prenatal Drug Exposure
In brief
Background: \- Recent research has suggested that prenatal exposure to drugs may affect specific brain processes, including working memory, stress response, and decision making. However, most of the research on the effects of prenatal drug exposure in humans has been conducted early in life, and very little is known about effects of prenatal drug exposure during the crucial brain development period that takes place during puberty and adolescence. The biological and psychological changes associated with puberty may increase adolescents' sensitivity to prenatal substance exposure. Researchers are interested in using functional magnetic resonance imaging (fMRI) scans to study brain function and learn more about the effects of prenatal drug exposure on adolescents. Objectives: \- To examine the effects of prenatal substance exposure on working memory, decision making, and normal brain activity in adolescents. Eligibility: \- Adolescents between 12 and 17 years of age who are enrolled in a larger follow-up study of children exposed to drugs in utero. Design: * The study will involve a single outpatient session with two fMRI scans that will test working memory and decision-making processes. * Participants will have brief medical history, a physical examination, and a urine test for drugs of abuse. * Participants will then be trained on the working memory and decision-making tasks before having an initial MRI scan to provide a baseline reading. * The fMRI scans will take 40 to 45 minutes each, and participants will have break in between as needed.
Key facts
- Study ID
- NCT01020669
- Run by
- National Institute on Drug Abuse (NIDA)
- People needed
- 24
- Starts
- 2009-10-16
- Expected to finish
- 2011-07-13
- Last updated by the study team
- 2017-07-02
Who can join
Age: 13 and older, up to 17. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Report of a history of significant medical/neurological illness that might interfere with imaging data such as HIV positive status, cerebral vascular accident (CVA), central nervous system (CNS) tumor, head trauma, multiple sclerosis (MS) or other demyelinating diseases, epilepsy, or movement disorders.
- Metallic devices in the body that preclude MRI scanning, as determined by self and parent (guardian) report.
- Current use of psychotropic medication that may alter attentional functioning (e.g., Clonidine, antipsychotics, Effexor, stimulants).
- Currently using respiratory, cardiovascular, anticonvulsant or other medications that might interfere with the mechanisms producing the BOLD signal.
- Currently abusing street drugs as assessed by history and urine testing.
- Pregnancy, which will be assessed by history during screening and by urine testing on scan days.
- Claustrophobia by self and/or parent (guardian) report severe enough to preclude toleration of the scanning environment.
Where it is running
- University of Maryland at Baltimore/MPRC — Catonsville, Maryland, United States
Full record on ClinicalTrials.gov
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