Absorption of Heme and Non-Heme Iron in Pregnant and Non-pregnant Women and Mechanisms of Fetal Iron Transfer
Completed
Conditions studied: Iron Deficiency
In brief
The three specific aims of this study are 1) to assess the impact of iron status on relative differences in absorption of heme and non-heme iron among pregnant women and non-pregnant women, 2) to assess the magnitude and the determinants of heme and non-heme iron transfer to the fetus over the last trimester of pregnancy, and 3) to characterize relationships between placental iron binding proteins with the enrichment of stable iron isotopes in the neonate at birth. The investigators hypothesize that there will be up regulation of heme and non-heme iron absorption and up regulation of placental iron transport proteins in response to low maternal iron stores.
Key facts
- Study ID
- NCT01019096
- Run by
- Cornell University
- People needed
- 55
- Starts
- 2008-05-01
- Expected to finish
- 2011-07-01
- Last updated by the study team
- 2012-03-22
Who can join
Age: 15 and older, up to 35. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Pregnant subjects (15-35 yrs): non-smoking,healthy with uncomplicated pregnancies at time of enrollment
- Non-pregnant subjects (18-35 yrs): healthy, non-smoking, not taking vitamin or mineral supplements and not planning on becoming pregnant during course of study.
You may not qualify if…
- Pregnant subjects: gestational diabetes, hypertension, preeclampsia, underlying malabsorption diseases or other diagnosed medical problems known to impact iron homeostasis
- Non-pregnant subjects: underlying malabsorption diseases or other diagnosed medical problems known to impact iron homeostasis.
Where it is running
- Highland Hospital — Rochester, New York, United States
- Strong Memorial Hospital — Rochester, New York, United States
Full record on ClinicalTrials.gov
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