Optimal Planning Target Volume With Stereotactic Radiosurgery

Completed · Not applicable

Conditions studied: Brain Neoplasms, Brain Cancer

In brief

The purpose of this study is to estimate the rate of local control at the treated site of the metastasis as a function of 1mm versus 3mm expansion about the gross tumor volume (GTV). Each lesion, not each patient will be ranndomized to either the 1mm or 3mm margin with 40 lesions randomized to each arm.

Key facts

Study ID

NCT01017497

Run by

Duke University

People needed

49

Starts

2009-12-01

Expected to finish

2013-12-01

Last updated by the study team

2015-02-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age >18 years
• Life expectancy of at least 6 months.
• Karnofsky Performance Score greater than 70
• Graded prognostic assessment (GPA score 0.5 or greater
• 1 to 3 brain metastases unresectable
• Maximum tumor diameter no larger than 4cm

You may not qualify if…

• Primary lesion with radiosensitive histology (such as: small cell carcinoma, germ-cell tumors, lymphoma, leukemia, and multiple myeloma.
• Metastases in the brain stem, pons or medulla or within 5 mm of optic apparatus
• Previous cranial radiation
• Pregnancy

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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