Fluorine F18-EF5 and Fludeoxyglucose F18 Positron Emission Tomography in Assessing Hypoxia and Glycolysis in Patients With Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer
Completed · Phase 1
Conditions studied: Non-small Cell Lung Cancer
In brief
RATIONALE: Diagnostic procedures, such as positron emission tomography, using the drug fluorine F18-EF5 to find oxygen and fludeoxyglucose F18 to find sugar in tumor cells may help in planning treatment for patients with non-small cell lung cancer.
Key facts
- Study ID
- NCT01017133
- Run by
- Abramson Cancer Center at Penn Medicine
- People needed
- 56
- Starts
- 2009-05-01
- Expected to finish
- 2012-09-01
- Last updated by the study team
- 2012-09-26
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects must have a histologically confirmed NSCLC or clinical and imaging evidence of a de novo mass that is likely to be a NSCLC, stage I, II, or IIIA, for which surgery would be indicated for routine medical indications
- ECOG performance status between 0 and 2
- Subjects must sign an informed consent document that indicates they are aware of the investigational nature of the treatment in this protocol as well as the potential risks and benefits
- WBC > 2,000/mm\^3
- Platelet count > 100,000/mm\^3
- Total bilirubin
- Serum AST and ALT
- Serum creatinine
- Negative serum pregnancy test if a female of childbearing age
You may not qualify if…
- History of allergic reactions attributed to Flagyl (metronidazole), which has a chemical structure similar to EF5
- Uncontrolled intercurrent illness that would limit compliance with study requirements
- Pregnant women and women who are breastfeeding are excluded
- Subjects who have been treated with neoadjuvant radiation or chemotherapy prior to their biopsy or excision are excluded because the impact of these therapies upon the degree of hypoxia of the tumor is unknown
Where it is running
- Abramson Cancer Center of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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