Dynamic Magnetic Resonance Imaging (MRI) for Lung Tumor Motion and Lung Function (GCC 0943)

Completed

Conditions studied: Lung Cancer

In brief

Radiation treatment for each patient with cancer is designed based on CT scans. We know that tumors in the chest and abdomen move when you breathe. Because of this, there can be differences between planned treatment and the treatment actually delivered to the body. Usually with radiation a safety margin is added to ensure that radiation hits the entire tumor. This can damage healthy parts of the body because the exact location of the tumor is unknown. Magnetic resonance imaging (MRI) is a painless and safe diagnostic procedure that uses a powerful magnet and radio waves to produce detailed images of the body's organs and structures, without the use of X-rays or other radiation. The research doctors are studying to see if the position of a tumor can be tracked using MRI scans and tracking sensors placed on the skin. MRI scans and the tracking system used to calculate the location and position of the tumor are both FDA approved technologies. The research doctors will also use the MRI scans to evaluate any changes in your lung function during and following your radiation treatments. In this study the participant will undergo a series of MRI scans with and without contrast dye. This study is being funded through grants from the National Institutes of Health (NIH).

Key facts

Study ID

NCT01016938

Run by

University of Maryland, Baltimore

People needed

16

Starts

2009-11-01

Expected to finish

2015-10-01

Last updated by the study team

2019-08-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients 18 years old or older
• Patients must be undergoing radiation therapy with or without chemotherapy for thoracic and/or abdominal cancers.

You may not qualify if…

• Pregnant or breast-feeding women are excluded. Negative serum or urine pregnancy test prior to study entry is required. Once on the protocol, the patient will be advised and expected to implement an accepted and effective method of contraception such as oral contraceptives (birthcontrol pill), intrauterine devices (IUDs), contraceptive implants under skin or contraceptive injections and condoms with foam.
• Patients with kidney disease of any severity or on hemodialysis.
• Patients who have metallic dental fillings or other metallic implants.
• Patients with known allergies to gadolinium-based contrast agents.
• Patients who have difficulty lying flat on their back for extended periods of time will be excluded

Where it is running

• Ummc Msgcc — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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