A Phase 1 Dose-escalation Trial of SGN-75 in CD70-positive Non-Hodgkin Lymphoma or Renal Cell Carcinoma

Completed · Phase 1

Conditions studied: Carcinoma, Renal Cell, Lymphoma, Non-Hodgkin

In brief

This is a phase 1, open-label, dose-escalation clinical trial to evaluate the safety of SGN-75 in patients with CD70-positive relapsed or refractory non-Hodgkin lymphoma or metastatic renal cell carcinoma.

Key facts

Study ID

NCT01015911

Run by

Seagen Inc.

People needed

58

Starts

2009-11-01

Expected to finish

2012-03-01

Last updated by the study team

2014-12-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Pathologically-confirmed diagnosis of NHL or RCC
• Relapsed, refractory, or progressive disease following at least 1 prior systemic therapy
• Confirmed CD70 expression
• Measurable disease, defined as at least 1 lesion >1.5 cm in the greatest transverse diameter for patients with NHL, and at least 1 non-resectable tumor lesion > or equal to 10 mm in diameter for patients with RCC

You may not qualify if…

• Previously received an allogeneic transplant
• History of another primary malignancy that has not been in remission for at least 3 years
• Prior anti-CD70-directed therapy

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• City of Hope National Medical Center — Duarte, California, United States
• UCLA Medical Center / University of California at Los Angeles — Los Angeles, California, United States
• Karmanos Cancer Institute / Wayne State University — Detroit, Michigan, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Memorial Sloan Kettering Cancer Center — New York, New York, United States
• Sarah Cannon Research Institute — Nashville, Tennessee, United States
• MD Anderson Cancer Center / University of Texas — Houston, Texas, United States
• Seattle Cancer Care Alliance / University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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