Risk of Psychopathology and Neurocognitive Impairment in Leukemia Survivors

Completed

Conditions studied: Neurocognitive Impairment, Acute Lymphoblastic Leukemia

In brief

1. This study will evaluate the association between changes in basic cognitive and behavioral functioning by the end of chemotherapy treatment, and the later development of higher order executive functions in pediatric acute lymphoblastic leukemia (ALL). 2. The association between acute treatment-related changes in brain integrity and subsequent brain maturation in long-term survivors of pediatric ALL will be evaluated. 3. The association between patterns of behavioral and executive dysfunction and brain maturation in long-term survivors of pediatric ALL will be examined. 4. The association between genetic polymorphisms in key enzyme pathways and higher order brain development in long-term survivors of pediatric ALL will be explored. 5. The associations between biologic and behavioral indices of fatigue/sleep and higher order brain development in long-term survivors of pediatric ALL will be explored.

Key facts

Study ID

NCT01014195

Run by

St. Jude Children's Research Hospital

People needed

237

Starts

2010-01-01

Expected to finish

2014-10-01

Last updated by the study team

2016-06-07

Who can join

Age: 8 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Enrolled on SJCRH TOTXV ALL protocol
• ≥ 5 years post diagnosis of ALL
• ≥ 8.0 years of age at time of follow-up evaluation

You may not qualify if…

• History of cranial or total-body radiation therapy
• History of bone marrow transplant
• History of relapse
• History of head injury, neurological condition unrelated to ALL treatment, or diagnosis of a genetic disorder associated with neurocognitive impairment (e.g. Down Syndrome)

Where it is running

• St. Jude Children's Research Hospital — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

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