Huperzine-A to Help With Mental Problems and the Inability to Care for Onself in Patients With Schizophrenia

Status unconfirmed · Phase 4

Conditions studied: Schizophrenia, Dementia

In brief

Use Huperzine-A, a herbal supplement normally used for treatment of Alzheimer's disease, to potentially improve cognitive dysfunction (memory problems) and functional capacity (ability to perform common daily tasks such as cooking, bathing, telephone, shopping) in people with schizophrenia.

Key facts

Study ID

NCT01012830

Run by

VA Nebraska Western Iowa Health Care System

People needed

15

Starts

2009-12-01

Expected to finish

2011-04-01

Last updated by the study team

2009-11-13

Who can join

Age: 19 and older, up to 59. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age 19-59
• diagnosis of schizophrenia by MINI
• cognition score 1 standard deviation below published norms in controls
• clinically stable for 12 weeks i.e. on the same antipsychotic(s) for 8 weeks and stable dose for at least 4 weeks
• have no more than moderate severity rating on hallucinations, delusions formal thought disorder (BPRS), negative symptoms (PANSS_N)
• minimal EPS (Simpson-Angus <6)
• minimal depression (Calgary <10)
• stable dose of other psychotropics (2 months)
• not pregnant.

You may not qualify if…

• history of active peptic ulcer disease within 1 year of screening
• clinically significant cardiac arrhythmia
• resting pulse less than 50
• active cancer (skin tumors other than melanoma are not excluded)
• history of clinically significant stroke
• current evidence or history in the past 2 years of epilepsy, focal brain lesion
• start of cholinesterase inhibitors/ cognitive enhancers (galantamine, rivastigmine, donepezil, vitamin E and memantine) within 2 months of screening, 8. use of medications with significant central nervous system anticholinergic activity within 2 months of screening.

Where it is running

• Veterans Affairs Nebraska Western Iowa Health Care System — Omaha, Nebraska, United States

Full record on ClinicalTrials.gov

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