Internal Monitoring of Eye Movement in Schizophrenia

Stopped early

Conditions studied: Schizophrenia

In brief

Background: * Researchers are studying how humans are able to move our eyes to a remembered region even when the target has disappeared. The ability to do this suggests that the brain can keep track of where the eyes have looked, without an external target for continued reference. This is called corollary discharge. * Other research has indicated that patients with schizophrenia might have difficulty monitoring their eye movements. The corollary discharge process may be defective in patients with schizophrenia, and perhaps delayed in time. Researchers have developed a test to examine this possibility in the hope of learning more about schizophrenia and eye movement. Objectives: \- To assess whether there is a defect in internal monitoring of eye movements in patients with schizophrenia. Eligibility: * Individuals over 18 years of age who are able to give informed consent and are able to concentrate on a 20-minute task that involves following projected targets and moving their eyes to remembered locations. * Individuals with schizophrenia will be recruited from an ongoing NIH protocol studying schizophrenia. * In addition healthy will be recruited for this protocol. Design: * Researchers will check participants' vision in each eye, and ask them to sit at a machine that measures eye movement in order to complete research tasks. Researchers will monitor participants ability to complete these tasks. * The first task involves simply following a target that jumps to different parts of the screen. * The second is a 2-step task, in which a participant is asked to look at two separate light targets and then look at the remembered target positions when the lights are off. * This protocol does not provide treatment. Participants will remain under the care of their own physicians during participation in this protocol.

Key facts

Study ID
NCT01011101
Run by
National Eye Institute (NEI)
People needed
2
Starts
2009-11-02
Expected to finish
2016-08-16
Last updated by the study team
2017-10-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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