Retinal Function in Parkinson's Disease

Status unconfirmed

Conditions studied: Parkinson's Disease

In brief

Parkinson's disease (PD) is a neurodegenerative disorder characterized by muscle rigidity, tremor, a slowing of physical movement (bradykinesia) and, in extreme cases, a loss of physical movement. The primary symptoms are the results of decreased stimulation of the motor cortex arising from the basal ganglia normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Secondary symptoms may include high level cognitive dysfunction and subtle language problems. Included in the symptomatology experienced by patients with PD, visual abnormalities are not uncommon. Visual changes among patients with PD appear not only dynamic in nature, but differentially affected based on the course of the disease and, perhaps more importantly, its treatment. Parkinson's disease has significant ramifications not only in observation of irregularities in vision, but how vision interacts with entrainment of the circadian clock. The purpose of this study is to examine the relationship between PD and operation of a unique set of retinal cells known to regulate the circadian clock and sleep-wake cycles in human subjects.

Key facts

Study ID
NCT01010074
Run by
US Department of Veterans Affairs
People needed
50
Starts
2009-10-01
Expected to finish
2010-12-01
Last updated by the study team
2009-11-09

Who can join

Age: 18 and older, up to 64. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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