Cixutumumab and Sorafenib Tosylate in Treating Patients With Advanced Liver Cancer

Completed · Phase 1

Conditions studied: Adult Hepatocellular Carcinoma, Advanced Adult Hepatocellular Carcinoma, Localized Non-Resectable Adult Liver Carcinoma, Recurrent Adult Liver Carcinoma

In brief

This phase I trial is studying the side effects and best dose of cixutumumab when given together with sorafenib tosylate in treating patients with advanced liver cancer. Monoclonal antibodies, such as cixutumumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving cixutumumab together with sorafenib tosylate may kill more tumor cells.

Key facts

Study ID: NCT01008566
Run by: National Cancer Institute (NCI)
People needed: 21
Starts: 2009-08-01
Last updated by the study team: 2016-05-12

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Unresectable or metastatic HCC for which standard curative measures do not exist; the diagnosis of hepatocellular carcinoma should be based on at least one of the following:
The presence of one or more liver lesions, measuring ≥ 2 cm, with characteristic arterial enhancement and venous washout in the setting of liver cirrhosis and/or hepatitis B or C infection
The presence of liver lesion(s) with AFP >= 400
Tissue confirmation in the absence of a and/or b
Tissue availability is desired and will be sought, but tissue availability is not mandated for accrual to the study
No prior systemic therapy for HCC; patients may have had prior embolization, chemoembolization, intra-arterial chemotherapy infusion, ethanol injection, radiofrequency ablation or cryosurgery
ECOG 0 or 1
Life expectancy of greater than 3 months
Absolute neutrophil count > 1,000/mm\^3
Platelets > 65,000/mm\^3
Total bilirubin =< 2 x the institutional upper normal limit
AST and ALT =< 5 x the institutional upper normal limit
Renal function =< 1.5 mg/dl or calculated creatinine clearance > 50 mL/min (Cockcroft-Gault formula)
PT < 4 seconds of prolongation above the upper normal limit
No evidence of encephalopathy in the last 6 months
Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation; should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately
Ability to understand and willing to sign a written informed consent document

You may not qualify if…

Local therapy for HCC within 4 weeks prior to treatment on this study or those who have not recovered from adverse events related to therapy administered more than 4 weeks earlier
Receiving other investigational agents
Brain metastases, because of their poor prognosis, proclivity for progressive neurologic dysfunction that would confound the evaluation of neurologic adverse events, and the potential for increased risk for CNS adverse events
Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, or psychiatric illness/social situations that would limit compliance with study requirements
Pregnant women are excluded from this study; breastfeeding should be discontinued if the mother is treated on this clinical trial
HIV-positive patients are ineligible
Fasting blood glucose > 160 mg/dL
Esophageal or gastric variceal bleeding within the last 6
Clinically evident ascites (minimal, medically controlled ascites detectable on imaging studies only is allowed)
Child-Pugh C cirrhosis or Child-Pugh B cirrhosis with more than 7 points
Patients unable to swallow the sorafenib tablets whole are ineligible; (the tablets cannot be crushed or broken)
Cardiac: symptomatic congestive heart failure, unstable angina, clinically significant and uncontrolled cardiac dysrhythmia, uncontrolled hypertension (systolic BP > 150 or diastolic BP > 100 on two occasions within two weeks of beginning therapy on this protocol, myocardial infarction within 6 months, NYHA class > II, LVEF < normal as assessed on MUGA
Fibrolamellar carcinoma or any mixed variants of HCC with fibrolamellar histology
Hypersensitivity to human IgG unless the patient has subsequently tolerated IgG agents
Patients with active hepatitis B infection should be on adequate antiviral therapy

Where it is running

City of Hope Comprehensive Cancer Center — Duarte, California, United States
USC / Norris Comprehensive Cancer Center — Los Angeles, California, United States
University of California Davis Comprehensive Cancer Center — Sacramento, California, United States
Penn State Hershey Cancer Institute-Clinical Trials Office — Hershey, Pennsylvania, United States
University of Pittsburgh Cancer Institute (UPCI) — Pittsburgh, Pennsylvania, United States
University of Pittsburgh Cancer Institute — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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