Investigation of Neuro-hormonal Mechanisms of Hunger, Fullness and Obesity.
Withdrawn before enrolling
Conditions studied: Obesity, Gastric Emptying, Anxiety, Depression, Panic Disorder
In brief
The purpose of this study is to determine abnormal neuro-hormonal mechanisms that may impair the ability to feel full and which therefore, may lead to obesity.
Key facts
- Study ID
- NCT01008371
- Run by
- Medical University of South Carolina
- People needed
- 0
- Starts
- 2009-10-01
- Expected to finish
- 2013-03-01
- Last updated by the study team
- 2013-05-22
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Males and females 18 to 65 years of age.
- Obese Subjects with BMI >40.
- Normal weight subjects with BMI = 18.5-24.9
You may not qualify if…
- Age younger than 18 years and over 65 years of age.
- Current use of narcotics or morphine
- Previous gastric surgery
- Presence of the following disorders that are known to cause functional gastric stasis syndromes: Diabetes Mellitus, Hypothyroidism, Progressive Systemic Sclerosis, Systemic Lupus Erythematosus, Dermatomyositis, Familial Dysautonomia, Pernicious Anemia, Bulbar poliomyelitis, Amyloidosis, Gastric Ulcer, Post-vagotomy, Tumor-associated gastroparesis, Fabry disease, Myotonic Dystrophy, Post-operative ileus, Gastroenteritis.
- Presence of the following disorders that are known to cause delayed gastric emptying: peptic ulceration, recent surgery, pyloric hypertrophy, post-radiotherapy, ileus, anorexia nervosa, acute viral infections.
- Presence of the following disorders that are known to cause rapid gastric emptying: Pyloroplasty, Hemigastrectomy, Duodenal ulcer, Gastrinoma (Zollinger-Ellison syndrome), Hyperthyroidism
- Current use of Thyroxine as it is known to cause rapid gastric emptying
- Current or recent (within the last 2 weeks) use of anti-spasmodics or pro-kinetic medications.
- Current use of Hyperalimentation
- Presence of any metabolic disorder, such as: hyperglycemia, acidosis, hypokalemia, hypercalcemia, hepatic coma or myxedema.
- Current use of estrogen or progesterone
- Current use of the following drugs that are known to delay gastric emptying: Nifedipine, beta-adrenergic agonists, Isoproterenol, Theophylline, Sucralfate, anticholinergics, Levodopa, diazepam, tricyclic antidepressants, phenothiazine, Progesterone, oral contraceptives, alcohol, nicotine, opiates.
- Allergy to eggs or wheat.
- Pregnancy.
Where it is running
- Medical University of South Carolina — Charleston, South Carolina, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.