Functional Magnetic Resonance Imaging of Opioid Withdrawal in Healthy Human Volunteers

Completed · Not applicable · Has a placebo group

Conditions studied: Substance-Related Disorders

In brief

Opioid medications are commonly used for pain relief. When given over time, physical dependence can occur. This results in unpleasant side effects--such as agitation and nausea--if opioid medications are suddenly stopped. However, we do not know how withdrawal affects the brain. We know that a medication named Ondansetron can help ease or prevent symptoms associated with opioid withdrawal. Through imaging of the brain by fMRI, we hope to see how opioid withdrawal, with and without the administration of ondansetron, affects brain activity.

Key facts

Study ID

NCT01006707

Run by

Stanford University

People needed

15

Starts

2010-11-01

Expected to finish

2013-07-01

Last updated by the study team

2017-11-17

Who can join

Age: 18 and older, up to 35. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Patients will be healthy male volunteers, ages 18-35.

You may not qualify if…

• Females were excluded due to menstrual cycle modulation of opioid response.
• We will exclude individuals with Raynaud's disease or a history of coronary artery disease.

Where it is running

• Stanford University School of Medicine — Stanford, California, United States

Full record on ClinicalTrials.gov

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