Ziprasidone in Early Onset Schizophrenia Spectrum Disorders

Completed · Phase 2

Conditions studied: Schizophrenia

In brief

This is an open trial of ziprasidone (ZIP) in children and adolescents. It is designed to provide pilot data on the magnitude of ZIP's antipsychotic effects in psychotic youth, dosing ranges, acute safety, and tolerability. This would then inform the design of a rigorous, randomized controlled trial of ZIP in the pediatric population. The primary study hypothesis is that the proportion of pediatric subjects responding to treatment with ziprasidone will be comparable or greater than reported in trials of ziprasidone in adults.

Key facts

Study ID

NCT01006551

Run by

University of North Carolina, Chapel Hill

People needed

40

Starts

2002-12-01

Expected to finish

2006-02-01

Last updated by the study team

2024-08-15

Who can join

Age: 6 and older, up to 19. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Between 6 and 19 years old, male or female.
• Significant psychotic symptoms defined by a behavior score of at least 4 (moderate) on at least one of the psychotic items of Positive and Negative Symptom Scale (PANSS) at baseline.
• Subjects will meet DSM IV criteria for schizophrenia, schizoaffective disorder, or schizophreniform disorder.
• Subjects will be free of depot antipsychotic medication for at least six months.
• Good physical health.
• The subject gives informed assent for the study and his/her guardian is able and willing to give informed consent.
• Mood stabilizing treatment (i.e., antidepressant, lithium, carbamazepine, valproate) will be permitted during the first eight weeks of the study only if the patient has been treated with the mood stabilizer for at least 30 days. Dosages will remain stable for the first 8 weeks unless change or discontinuation is clinically indicated.

You may not qualify if…

• A primary diagnosis of substance abuse or dependence.
• Known endocrinological or neurological conditions, which confound the diagnosis or are a contraindication to treatment with antipsychotics.
• Subjects with a clear history of intolerance or nonresponsiveness to ziprasidone.
• Subjects at serious, short term risk for suicide.
• Subjects who are pregnant or who refuse to practice contraception during the study.
• Subjects with known cardiac conduction problems especially prior QTc prolongation, known genetic risk for QTc prolongation or who are being treated with other agents that prolong the QTc. These agents include the antiarrhythmic agents: dofetilide (Tikosyn), sotalol (Betapace), quinidine (Quinaglute), or Class 1A and III antiarrhythmics; the antipsychotics mesoridazine (Serentil), thioridazine (Mellaril), chlorpromazine (Thorazine), droperidol (Inapsine), pimozide (Orap); the anti-infectives: sparfloxacin (Zagam), gatifloxacin (Tequin), moxifloxacin (Avelox), pentamidine (Pentam); the anti-malarials halofantrine (Halfan), mefloquine (Lariam); and arsenic trioxide (Trisenox), levomethadyl acetate (Orlaam), dolasetron mesylate (Anzemet), probucol (Lorelco-an antilipemic), and tacrolimus (Prograf).
• Subjects with a diagnosis of a pervasive developmental disorder or an autism screening questionnaire score >15, must have clear hallucinations or delusions.
• Subjects will be excluded if they meet criteria for a current major depressive episode.

Where it is running

• Harvard University — Medford, Massachusetts, United States
• University of North Carolina, Chapel Hill — Chapel Hill, North Carolina, United States
• Case Western Reserve University — Cleveland, Ohio, United States
• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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