A Trial of N-Acetylcysteine (an Over-the-Counter Medicine) in Adolescents Who Smoke Marijuana

Completed · Phase 2 · Has a placebo group

Conditions studied: Cannabis Dependence

In brief

This study is investigating how N-Acetylcysteine (NAC), an over-the-counter medication, will reduce marijuana use when combined with Contingency Management, a behavioral treatment. It is hypothesized that marijuana dependent adolescents who are treated with NAC will use less marijuana during treatment when compared to adolescents who receive a placebo.

Key facts

Study ID

NCT01005810

Run by

Medical University of South Carolina

People needed

116

Starts

2009-09-01

Expected to finish

2011-08-01

Last updated by the study team

2018-11-21

Who can join

Age: 13 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 13-21 years
• Regular Marijuana smoker meeting DSM-IV criteria for cannabis dependence and seeking marijuana cessation treatment

You may not qualify if…

• Allergy or intolerance to NAC
• Pregnancy or lactation
• Use of carbamazepine or nitroglycerine (or any other drug deemed to be hazardous if taken with NAC) within 14 days of study participation
• Current enrollment in treatment for cannabis dependence
• Current substance dependence, other than cannabis or nicotine
• Significant medical or psychiatric illness that may place the participant at increased risk in the judgement of the study physician

Where it is running

• Medical University of South Carolina — Charleston, South Carolina, United States

Full record on ClinicalTrials.gov

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