Molecular and Morphologic Characterization of Circulating Endothelial Cells

Running, not enrolling

Conditions studied: Acute Myocardial Infarction

In brief

The primary hypothesis of this study is that circulating endothelial cells (CECs) harbor key genetic and structural characteristics predisposing individuals to acute atherosclerotic plaque rupture and heart attack.

Key facts

Study ID

NCT01005485

Run by

Scripps Translational Science Institute

People needed

664

Starts

2010-01-01

Expected to finish

2025-12-01

Last updated by the study team

2025-01-17

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18 - 80 years old.
• Must be reliable, cooperative and willing to comply with all protocol-specified procedures if consented.
• Able to understand and grant informed consent
• Subjects must meet one of the following (a-c):
• Healthy control subjects not meeting any exclusion criteria for controls below
• Patients scheduled for an open vascular procedure of an arterial structure
• Patients with acute MI defined as:
• i. Clinical history and symptoms consistent with acute MI AND ii Elevated cardiac markers (CKMB, Troponin I or T) consistent with MI (abnormals are according to enrolling institution's lab standards) AND iii. Able to complete study enrollment (consent \& blood draw) within 48 hours of presentation to the study site.

You may not qualify if…

• General Exclusion Criteria:
• Has a significant medical condition that in the investigator's opinion may interfere with the patient's optimal participation in the study.
• Exclusion for Healthy Controls:
• Age greater than 35
• Previous history of coronary artery disease or MI
• Diabetes
• Peripheral arterial disease
• Hypertension (>140/90 or on blood pressure medication)
• Sickle cell disease
• Acute or Chronic kidney disease
• Acute or Chronic vascular conditions, not otherwise specified
• Active or history of inflammation of connective tissue and vascular structures (i.e. vasculitis, rheumatoid arthritis)

Where it is running

• Scrippshealth — La Jolla, California, United States

Full record on ClinicalTrials.gov

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